Squarespace is by far the easiest way to create a slick One Page website. Their templates and support are both excellent. Learn more.
Unique One Page Website Review
Clean design with a beautiful scheme!
Used a responsive one page framework called Cool Kitten, threw in jQuery Cycle, and Spritely for the animated, walking, talking Vagina - making it pretty easy to throw this page up in a couple of hours. Woo!